Sofosbuvir 400 mg is a prescription antiviral medication used in the treatment of chronic Hepatitis C virus (HCV) infection in adults. It is usually taken in combination with other antiviral medicines (such as Ledipasvir, Daclatasvir, or Ribavirin) to improve the chances of curing Hepatitis C. Sofosbuvir helps prevent the virus from multiplying in the body, ultimately reducing the viral load and leading to long-term clearance of the virus.
Medicinal Benefits:
- Belongs to a class of drugs called direct-acting antivirals (DAAs)
- Inhibits the HCV NS5B RNA-dependent RNA polymerase, a key enzyme required for the virus to replicate
- When used in combination therapy, it offers high cure rates for Hepatitis C across various genotypes
- Reduces the risk of liver complications, including cirrhosis and liver cancer
How It Works:
Sofosbuvir targets and blocks the action of the NS5B polymerase, an enzyme essential for Hepatitis C virus replication. This stops the virus from multiplying, helping your body eliminate the infection over time when taken consistently with other antivirals.
Directions for Use:
- Dosage: Usually 400 mg once daily, or as directed by your healthcare provider.
- Administration: Take the tablet with or without food, preferably at the same time every day.
- Important: Always take it in combination with other antiviral drugs; never use Sofosbuvir alone.
Storage Instructions:
- Store at room temperature, away from moisture and direct sunlight.
- Keep out of reach of children.
Common Side Effects:
When used in combination with other antivirals, side effects may include:
- Headache
- Fatigue
- Nausea
- Insomnia
- Anemia (especially with Ribavirin)
Most side effects are mild and resolve over time. Seek medical help if you experience severe fatigue, shortness of breath, or yellowing of the skin/eyes.
Precautions and Warnings:
- Pregnancy: Not recommended with Ribavirin combination due to risk of birth defects.
- Breastfeeding: Consult your doctor before use.
- Drug Interactions: Inform your doctor about all medicines, especially antiepileptics, antacids, or tuberculosis medications.
- HIV or HBV Co-infection: Should be monitored closely during treatment.
Alcohol and Sofosbuvir:
- Avoid alcohol during treatment as it may worsen liver function and reduce drug effectiveness.
Special Advice:
- Complete the full treatment course even if you feel better.
- Routine liver function tests and viral load tests may be required during treatment.
- This medication does not prevent reinfection, so avoid risky behaviors such as sharing needles.
Country of Origin: INDIA
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