Ledipasvir & Sofosbuvir is a fixed-dose combination antiviral medicine used to treat chronic Hepatitis C virus (HCV) infection, particularly genotypes 1, 4, 5, and 6. This once-daily oral treatment helps eliminate the virus from the body and is known to offer a very high cure rate when taken consistently over 8–12 weeks.
Medicinal Benefits:
- Ledipasvir is an HCV NS5A inhibitor that blocks viral replication and assembly.
- Sofosbuvir is an HCV NS5B polymerase inhibitor that blocks the replication of viral RNA.
- Together, they work synergistically to stop the virus from multiplying and clear the infection from the blood.
- Significantly lowers the risk of liver damage, cirrhosis, and liver cancer.
- Suitable for patients with or without HIV co-infection.
Uses:
- Chronic Hepatitis C (genotypes 1, 4, 5, and 6)
- Treatment-naïve and treatment-experienced patients
- With or without compensated cirrhosis
How It Works:
- Ledipasvir blocks a protein (NS5A) that the Hepatitis C virus needs to reproduce and assemble new viral particles.
- Sofosbuvir targets another protein (NS5B polymerase) that helps the virus make copies of its RNA.
- Together, they stop the virus at multiple stages, leading to effective viral clearance.
Directions for Use:
- Dosage: One tablet once daily, or as directed by your physician.
- Administration: Take with or without food. Swallow whole with water.
- Treatment Duration: Usually 8 to 12 weeks, depending on liver condition, genotype, and prior treatment history.
Storage Instructions:
- Store in a cool, dry place, away from direct sunlight.
- Keep out of reach of children.
Common Side Effects:
Most are mild and temporary:
- Fatigue
- Headache
- Nausea
- Diarrhea
- Insomnia
- Irritability
Serious allergic reactions are rare but require immediate medical attention.
Precautions and Warnings:
- Pregnancy & Breastfeeding: Consult a doctor; may be used with caution if clearly needed.
- Children: Not recommended for patients under 18 years of age.
- Kidney or Liver Problems: Inform your doctor before starting treatment.
- Drug Interactions: Avoid antacids, rifampin, amiodarone, and certain anti-epileptics (e.g., phenytoin, carbamazepine).
- HIV or HBV Co-infection: Monitor closely during therapy.
Alcohol and This Medication:
- Avoid alcohol as it may worsen liver health and interfere with treatment effectiveness.
Special Advice:
- Complete the full course even if symptoms improve early.
- Regular blood tests may be required to monitor liver function and viral response.
- Not a vaccine — does not prevent future infections with Hepatitis C.
Country of Origin: INDIA
Reviews
There are no reviews yet.